David B. Cooke III
Professor / Chair
Ph.D Thesis:
Education:
B.S. North Carolina Central University
M.S. North Carolina Central University
Ph.D. Howard University, College of Medicine, Department of Physiology
and Biophysics
Fellowship: University of North Carolina at Chapel Hill; Lineberger
Cancer Research Center
BS:
Subject, Institution, Year
MS: Subject, Institution, Year
Ph.D: Physiology, Howard
University, 1983
Research Interests:
Endocrinology and Cell Metabolism
Role of Oncogene
Expression in Prostate Cancer
Tumor Progression in Prostate Cancer
Research in this laboratory utilizes the
Dunning R-3327 rat dorsal prostatic adenocarcinoma system. This spontaneously developing
cancer consists of several well defined sublines
which exhibit varying stages of tumor progression similar to that of human
prostate cancer. Our study of prostate cancer has demonstrated correlations
between metastatic oncogene
expression (ras family) and cellular
differentiation (retinoic acid, diflouromethyl ornithine). The metastatic
process involves the ability of a proliferative
cellular mass to be motile, which suggests a deregulation of genetic and
cellular controls. To this end, we have utilized invasion, chemoinvasion and adhesion assays as a means of
distinguishing the metastatic phenomenom.
In addition, confocal laser microscopy has been
utilized to elucidate changes in the distribution of cytoskeletal
proteins (actin, alpha-actinin,
vinculin,vimentin) as a
means of characterizing the metastatic process. In
sum, this laboratory seeks to further characterize genotypic and phenotypic
entities associated with tumor progression of the prostate as well as to
demonstrate how differentiation therapy could be utilized as a tool for tumor
suppression.
Selected Publications:
Donald, C., D.E. Montgomery, N.Emmett
and D.B. Cooke, III. 1999. Invasive potential and substrate dependence of
attachment in the Dunning R-3327 rat prostate adenocarcinoma
model. Invasion and Metastasis (accepted for publication).
Blount, L.V. and D.B. Cooke, III. 1996. Genomic methylation patterns of the Dunning R-3327 prostatic adenocarcinoma
system. Cancer Letters 98(2)213-218.
Blount, L.V. and D.B. Cooke, III. 1996. Point mutations
in the Ki-ras2 gene of codon12 in the Dunning R-3327 prostatic
adenocarcinoma system. Prostate 28(1):44-50.
Cooper, C.R., N. Emmett, S. Harris-Hooker, R. Patterson
and D.B. Cooke, III. 1994. Biometric assessment of prostate cancer metastatic potential. World Journal of Urology
12(6):304-307.
Cooper, C.R.,
C.D. Donald, N. Emmet, S. Harris-Hooker, D.B.
Cooke, III. 1993. The adhesion and invasion potential of rat prostatic cancer cells: A correlation with metastatic potential. Invasion and Metastasis 13:169-177.
Office: Nabrit-Mapp-McBay Science Building
(404) 215-2609
(404) 681-2800 x2323
FAX (404) 522-9564
dcooke@morehouse.edu
Last Updated:
Aug. 25, 03 / Porsch R. Fallen
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